Welcome to the webpage of the project: “In Silico Modelling, Prediction, Synthesis and Biological Evaluation of Novel Rheumatoid Arthritis Inhibitors” (2009-2011)
The aim of the project was the rational drug design, with the development of in silico modeling methods, synthesis and biological evaluation of new active Rheumatoid Arthritis small molecules. The developed method, due to the high predictive ability and simplicity, could be a useful aid to the costly and time-consuming experiments for determining the TNF-a inhibition. The method can also be used to screen existing databases or virtual combinations to identify derivatives with desired activity. The developed in silico workflows to help researchers to design novel chemistry driven molecules with desired biological activity.
«This Project was funded under «ΕΠΙΧΕΙΡΗΣΕΙΣ Programme» of the Research Promotion Foundation’s (RPF) «Framework Programme for Research, Technological Development and Innovation 2008» (DESMI 2008), Grant Number: ΕΠΙΧΕΙΡΗΣΕΙΣ/ΕΦΑΡΜ /0308/20. DESMI 2008 is co-funded by the Republic of Cyprus and the European Regional Development Fund of the EU.»